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A potential role for T-type calcium channels in homocysteinemia-induced peripheral neuropathy

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dc.contributor.author Gaifullina A.
dc.contributor.author Lazniewska J.
dc.contributor.author Gerasimova E.
dc.contributor.author Burkhanova G.
dc.contributor.author Rzhepetskyy Y.
dc.contributor.author Tomin A.
dc.contributor.author Rivas-Ramirez P.
dc.contributor.author Huang J.
dc.contributor.author Cmarko L.
dc.contributor.author Zamponi G.
dc.contributor.author Sitdikova G.
dc.contributor.author Weiss N.
dc.date.accessioned 2020-01-15T22:05:36Z
dc.date.available 2020-01-15T22:05:36Z
dc.date.issued 2019
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/156598
dc.description.abstract Homocysteinemia is a metabolic condition characterized by abnormally high level of homocysteine in the blood and is considered to be a risk factor for peripheral neuropathy. However, the cellular mechanisms underlying toxic effects of homocysteine on the processing of peripheral nociception have not yet been investigated comprehensively. Here, using a rodent model of experimental homocysteinemia, we report the causal association between homocysteine and the development of mechanical allodynia. Homocysteinemia-induced mechanical allodynia was reversed on pharmacological inhibition of T-type calcium channels. In addition, our in vitro studies indicate that homocysteine enhances recombinant T-type calcium currents by promoting the recycling of Cav3.2 channels back to the plasma membrane through a protein kinase C-dependent signaling pathway that requires the direct phosphorylation of Cav3.2 at specific loci. Altogether, these results reveal an unrecognized signaling pathway that modulates the expression of T-type calcium channels, and may potentially contribute to the development of peripheral neuropathy associated with homocysteinemia.
dc.title A potential role for T-type calcium channels in homocysteinemia-induced peripheral neuropathy
dc.type Article
dc.relation.ispartofseries-issue 12
dc.relation.ispartofseries-volume 160
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 2798
dc.source.id SCOPUS-2019-160-12-SID85074965976


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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