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Production and application of multicistronic constructs for various human disease therapies

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dc.contributor.author Shaimardanova A.
dc.contributor.author Kitaeva K.
dc.contributor.author Abdrakhmanova I.
dc.contributor.author Chernov V.
dc.contributor.author Rutland C.
dc.contributor.author Rizvanov A.
dc.contributor.author Chulpanova D.
dc.contributor.author Solovyeva V.
dc.date.accessioned 2020-01-15T22:02:27Z
dc.date.available 2020-01-15T22:02:27Z
dc.date.issued 2019
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/156539
dc.description.abstract © 2019 by the authors. Licensee MDPI, Basel, Switzerland. The development of multicistronic vectors has opened up new opportunities to address the fundamental issues of molecular and cellular biology related to the need for the simultaneous delivery and joint expression of several genes. To date, the examples of the successful use of multicistronic vectors have been described for the development of new methods of treatment of various human diseases, including cardiovascular, oncological, metabolic, autoimmune, and neurodegenerative disorders. The safety and effectiveness of the joint delivery of therapeutic genes in multicistronic vectors based on the internal ribosome entry site (IRES) and self-cleaving 2A peptides have been shown in both in vitro and in vivo experiments as well as in clinical trials. Co-expression of several genes in one vector has also been used to create animal models of various inherited diseases which are caused by mutations in several genes. Multicistronic vectors provide expression of all mutant genes, which allows the most complete mimicking disease pathogenesis. This review comprehensively discusses multicistronic vectors based on IRES nucleotide sequence and self-cleaving 2A peptides, including its features and possible application for the treatment and modeling of various human diseases.
dc.subject 2A peptides
dc.subject Autoimmune diseases
dc.subject Cancer
dc.subject Cardiovascular diseases
dc.subject Gene therapy
dc.subject IRES
dc.subject Metabolic diseases
dc.subject Multicistronic constructs
dc.subject Neurodegenerative diseases
dc.title Production and application of multicistronic constructs for various human disease therapies
dc.type Review
dc.relation.ispartofseries-issue 11
dc.relation.ispartofseries-volume 11
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS-2019-11-11-SID85074723639


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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