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Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients

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dc.contributor.author Serebriiskii I.
dc.contributor.author Connelly C.
dc.contributor.author Frampton G.
dc.contributor.author Newberg J.
dc.contributor.author Cooke M.
dc.contributor.author Miller V.
dc.contributor.author Ali S.
dc.contributor.author Ross J.
dc.contributor.author Handorf E.
dc.contributor.author Arora S.
dc.contributor.author Lieu C.
dc.contributor.author Golemis E.
dc.contributor.author Meyer J.
dc.date.accessioned 2020-01-15T22:01:20Z
dc.date.available 2020-01-15T22:01:20Z
dc.date.issued 2019
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/156519
dc.description.abstract © 2019, The Author(s). Colorectal cancer (CRC) is increasingly appreciated as a heterogeneous disease, with factors such as microsatellite instability (MSI), cancer subsite within the colon versus rectum, and age of diagnosis associated with specific disease course and therapeutic response. Activating oncogenic mutations in KRAS and NRAS are common in CRC, driving tumor progression and influencing efficacy of both cytotoxic and targeted therapies. The RAS mutational spectrum differs substantially between tumors arising from distinct tissues. Structure-function analysis of relatively common somatic RAS mutations in G12, Q61, and other codons is characterized by differing potency and modes of action. Here we show the mutational profile of KRAS, NRAS, and the less common HRAS in 13,336 CRC tumors, comparing the frequency of specific mutations based on age of diagnosis, MSI status, and colon versus rectum subsite. We identify mutation hotspots, and unexpected differences in mutation spectrum, based on these clinical parameters.
dc.title Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients
dc.type Article
dc.relation.ispartofseries-issue 1
dc.relation.ispartofseries-volume 10
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS-2019-10-1-SID85071011620


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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