Effects of Pesticides on Development of Tape 2 Diabetes Mellitus

Abstract

© 2019 IOP Publishing Ltd. All rights reserved. Scope and quality of studies on direct or indirect (through obesity) effects of pesticides on the whole and certain drugs on type 2 diabetes mellitus (DM2) acquiring epidemic proportions vary widely, not allowing to draw firm conclusions. To identify significance and degree of dependence of incidence rates of type 2 diabetes mellitus and obesity in adult population on the use of pesticides and new till technologies at regional level. Reports of the Ministry of Health and the Ministry of Ecology of the Republic of Tatarstan for the period from 2004 to 2016 were used. Cause and effect relationships of the parameters were assessed by means of multiple correlation and regression analysis with subsequent disperse one. Out of 116 992 patients with DM2 registered in the Republic, 116 977 were from the adult population. Relationships of DM2 (r=0.85) and obesity (0.71) prevalence with use of glyphosate preparations, tillage area according to no-till (r=0.97 and 0.89) and reduced-till (0.72 and 0.63) technologies were revealed. Correlation of agricultural indices with incidence of new cases of DM2 and obesity becomes significant only during the second-third year. The model of DM2 prevalence in case of the greatest effect of the volume of glyphosate use (R2=0.98; p<0.003), which correlated closely with the area with reduced-till and no-till technology (0.93 and 0.92; p<0.0001), was identified as the only one as informative (R2=0.93) and adequate of the variants of incidence rates of DM2, obesity and use of herbicides analysis. Increase of consumption of glyphosate-containing herbicides in conditions of no-till and reduced-till technologies contributes to growth of diabetes mellitus and obesity prevalence in adult population.