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Bumetanide prevents brain trauma-induced depressive-like behavior

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dc.contributor.author Goubert E.
dc.contributor.author Altvater M.
dc.contributor.author Rovira M.
dc.contributor.author Khalilov I.
dc.contributor.author Mazzarino M.
dc.contributor.author Sebastiani A.
dc.contributor.author Schaefer M.
dc.contributor.author Rivera C.
dc.contributor.author Pellegrino C.
dc.date.accessioned 2020-01-15T21:48:16Z
dc.date.available 2020-01-15T21:48:16Z
dc.date.issued 2019
dc.identifier.issn 1662-5099
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/156074
dc.description.abstract © 2019 Goubert, Altvater, Rovira, Khalilov, Mazzarino, Sebastiani, Schaefer, Rivera and Pellegrino. Brain trauma triggers a cascade of deleterious events leading to enhanced incidence of drug resistant epilepsies, depression, and cognitive dysfunctions. The underlying mechanisms leading to these alterations are poorly understood and treatment that attenuates those sequels are not available. Using controlled-cortical impact as an experimental model of brain trauma in adult mice, we found a strong suppressive effect of the sodium-potassium-chloride importer (NKCC1) specific antagonist bumetanide on the appearance of depressive-like behavior. We demonstrate that this alteration in behavior is associated with an impairment of post-traumatic secondary neurogenesis within the dentate gyrus of the hippocampus. The mechanism mediating the effect of bumetanide involves early transient changes in the expression of chloride regulatory proteins and qualitative changes in GABA(A) mediated transmission from hyperpolarizing to depolarizing after brain trauma. This work opens new perspectives in the early treatment of human post-traumatic induced depression. Our results strongly suggest that bumetanide might constitute an efficient prophylactic treatment to reduce neurological and psychiatric consequences of brain trauma.
dc.relation.ispartofseries Frontiers in Molecular Neuroscience
dc.subject Bumetanide
dc.subject Depression
dc.subject Interneuron cell death
dc.subject Neurogenesis
dc.subject Potassium chloride cotransporter 2 (KCC2)
dc.subject Psychiatric disease
dc.title Bumetanide prevents brain trauma-induced depressive-like behavior
dc.type Article
dc.relation.ispartofseries-volume 12
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS16625099-2019-12-SID85064230089


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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