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In seroconverted rheumatoid arthritis patients a multi-reactive anti-herpes IgM profile is associated with disease activity

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dc.contributor.author Larionova R.
dc.contributor.author Arleevskaya M.
dc.contributor.author Kravtsova O.
dc.contributor.author Validov S.
dc.contributor.author Renaudineau Y.
dc.date.accessioned 2020-01-15T21:47:50Z
dc.date.available 2020-01-15T21:47:50Z
dc.date.issued 2019
dc.identifier.issn 1521-6616
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/156014
dc.description.abstract © 2019 Elsevier Inc. Conflicting results have been reported regarding human herpes virus (HHV) reactivation in patients with rheumatoid arthritis (RA). To explore this link, 74 RA patients were selected and compared to 42 first degree relatives (FDR) from probands with RA and 25 healthy controls from the Tatarstan women cohort. The serological analysis was done by testing anti-HSV/CMV/EBV IgM, IgG, plus the IgG avidity index, and completed by evaluating HSV/CMV/EBV DNA by PCR. Results from these analyses reveal: (i) a long lasting infection of HHV in RA, FDR and healthy controls (IgG seroconversion >97%); (ii) an elevated IgM anti-HHV response in seroconverted RA patients which is related to HSV1/2 reactivation (HSV1/2 PCR+); and (iii) a multi-reactive IgM HHV burden profile associated with disease activity (DAS28). In conclusion, HSV1/2 reactivation in seroconverted RA patients is associated with an abnormal anti-HHV immune response, which was reflected in IgM HHV burden, and in activity disease profile.
dc.relation.ispartofseries Clinical Immunology
dc.subject CMV
dc.subject Disease activity
dc.subject EBV
dc.subject HSV
dc.subject Reactivation
dc.subject Rheumatoid arthritis
dc.title In seroconverted rheumatoid arthritis patients a multi-reactive anti-herpes IgM profile is associated with disease activity
dc.type Article
dc.relation.ispartofseries-volume 200
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 19
dc.source.id SCOPUS15216616-2019-200-SID85060341807


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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