Kazan Federal University Digital Repository

Thermally induced cyclization of <inf>L</inf>-isoleucyl-<inf>L</inf>-alanine in solid state: Effect of dipeptide structure on reaction temperature and self-assembly

Show simple item record

dc.contributor.author Ziganshin M.
dc.contributor.author Larionov R.
dc.contributor.author Gerasimov A.
dc.contributor.author Ziganshina S.
dc.contributor.author Klimovitskii A.
dc.contributor.author Khayarov K.
dc.contributor.author Mukhametzyanov T.
dc.contributor.author Gorbatchuk V.
dc.date.accessioned 2020-01-15T21:46:09Z
dc.date.available 2020-01-15T21:46:09Z
dc.date.issued 2019
dc.identifier.issn 1075-2617
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/155772
dc.description.abstract © 2019 European Peptide Society and John Wiley & Sons, Ltd. Thermal treatment of short-chain oligopeptides is able to initiate the process of their self-assembly with the formation of organic nanostructures with unique properties. On the other hand, heating can lead to a chemical reaction with the formation of new substances with specific properties and ability to form structures with different morphology. Therefore, in order to have a desired process, researcher needs to find its temperature range. In the present work, cyclization of L-isoleucyl-L-alanine dipeptide in the solid state upon heating was studied. Kinetic parameters of this reaction were estimated within the approaches of the nonisothermal kinetics. The correlation between side chain structure of dipeptides and temperature of their cyclization in the solid state was found for the first time. This correlation may be used to predict the temperature, at which dipeptide self-assembly changes to chemical reaction. The differences in self-assembly of linear and cyclic dipeptides were demonstrated using atomic force microscopy. The effect of dipeptide concentration in a source solution and an organic solvent used on self-assembly of dipeptides was shown. The new information obtained on the thermal properties and self-assembly of linear and cyclic forms of L-isoleucyl-L-alanine may be useful for the design of new nanomaterials based on oligopeptides, as well as for the synthesis of cyclic oligopeptides.
dc.relation.ispartofseries Journal of Peptide Science
dc.subject cyclization of dipeptide
dc.subject kinetic analysis
dc.subject organic nanostructures
dc.subject self-assembly of dipeptide
dc.subject solid-state reaction
dc.subject structure-property correlation
dc.title Thermally induced cyclization of <inf>L</inf>-isoleucyl-<inf>L</inf>-alanine in solid state: Effect of dipeptide structure on reaction temperature and self-assembly
dc.type Article
dc.relation.ispartofseries-issue 8
dc.relation.ispartofseries-volume 25
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS10752617-2019-25-8-SID85069517007


Files in this item

This item appears in the following Collection(s)

  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics