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Electrochemical DNA sensors on the basis of electropolymerized thionine and Azure B with addition of pillar[5]arene as an electron transfer mediator

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dc.contributor.author Stoikov D.
dc.contributor.author Porfir'eva A.
dc.contributor.author Shurpik D.
dc.contributor.author Stoikov I.
dc.contributor.author Evtyugin G.
dc.date.accessioned 2020-01-15T21:45:48Z
dc.date.available 2020-01-15T21:45:48Z
dc.date.issued 2019
dc.identifier.issn 1066-5285
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/155723
dc.description.abstract © 2019, Springer Science+Business Media, Inc. A DNA sensor was developed on the basis of glassy carbon electrode coated with polymeric forms of thionine and Azure B. Introduction of carbon black and pillar[5]arene into the electrode composition increases the efficiency of polymerization and the oxidation peak currents of dyes due to the mediating effect of the macrocycle. The addition of DNA onto the sensor surface and into the reaction mixture differently influences the electrochemical activity of poly(Azure B) and polythionine. The control of changes in current-voltage characteristics allowed us to identify the heat denaturation of DNA and its oxidation by reactive oxygen species generated upon the reaction of hydrogen peroxide and copper(II) salt. The DNA sensors can find application in the diagnosis of DNA damage on exposure to carcinogens and in screening of cytotoxic anticancer drugs.
dc.relation.ispartofseries Russian Chemical Bulletin
dc.subject biosensor
dc.subject DNA damage
dc.subject electropolymerization
dc.subject pillar[5]arene
dc.subject polythionine
dc.title Electrochemical DNA sensors on the basis of electropolymerized thionine and Azure B with addition of pillar[5]arene as an electron transfer mediator
dc.type Article
dc.relation.ispartofseries-issue 2
dc.relation.ispartofseries-volume 68
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 431
dc.source.id SCOPUS10665285-2019-68-2-SID85064449688


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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