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Peak window correlation method for drug screening using Raman spectroscopy

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dc.contributor.author Galeev R.
dc.contributor.author Semanov D.
dc.contributor.author Galeeva E.
dc.contributor.author Falaleeva T.
dc.contributor.author Aryslanov I.
dc.contributor.author Saveliev A.
dc.contributor.author Davletshin R.
dc.date.accessioned 2020-01-15T21:18:47Z
dc.date.available 2020-01-15T21:18:47Z
dc.date.issued 2019
dc.identifier.issn 0731-7085
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/155652
dc.description.abstract © 2018 Elsevier B.V. Modern portable and hand-held Raman spectrometers that recently have become widespread in drug quality screening have good reproducibility and are able to detect small concentrations of substances in mixtures of several components or distinguish compounds similar in structure and having minimal differences in spectrum with appropriate mathematical processing methods. Among other spectrum comparison approaches, the peak search at their location is the most important task of spectral imaging of the studied samples. In this work, the Raman spectra of liquid drugs involved in the governmental non-destructive quality screening program performed by 8 mobile laboratories equipped with Raman spectrometers with uncooled detector and a 532 nm laser were compared with reference sample spectra using the peak windows correlation (PWC) algorithm developed in this work by authors. The proposed method provides accurate identification, detection of composition changes, and presence of foreign components in drugs formulations even if their contribution to the overall signal is negligible. The spectral correlation method called hit-quality index (HQI) method conventionally used for such portable spectrometers was specified as comparative method.
dc.relation.ispartofseries Journal of Pharmaceutical and Biomedical Analysis
dc.subject Mathematical processing of spectra
dc.subject Medicine
dc.subject Quality screening
dc.subject Raman spectroscopy
dc.subject Search of peaks
dc.subject The peak windows correlation
dc.title Peak window correlation method for drug screening using Raman spectroscopy
dc.type Article
dc.relation.ispartofseries-volume 163
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 9
dc.source.id SCOPUS07317085-2019-163-SID85054007547


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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