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Application of the normalized relative error distribution analysis for non-destructive quality control of drugs by Raman spectroscopy

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dc.contributor.author Galeev R.
dc.contributor.author Saveliev A.
dc.contributor.author Galeeva E.
dc.contributor.author Falaleeva T.
dc.contributor.author Aryslanov I.
dc.contributor.author Semanov D.
dc.contributor.author Davletshin R.
dc.date.accessioned 2020-01-15T21:18:40Z
dc.date.available 2020-01-15T21:18:40Z
dc.date.issued 2019
dc.identifier.issn 0377-0486
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/155637
dc.description.abstract © 2019 John Wiley & Sons, Ltd. Development of drug quality control methods using non-invasive methods, in particular Raman spectroscopy, is an important task in the pharmaceutical industry. This paper presents a new approach to the analysis of drug spectra obtained with portable Raman spectrometers. It represents a normalized relative error distribution analysis (nReDA). The proposed method uses the Pearson residuals distribution statistics and, compared with the correlation method, allows increasing the screening sensitivity to foreign components that are not contained in the original sample, with the same resistance to changes in the noise distribution and the peak ratios. On the basis of the statistical data, the nReDA in some way is similar to the techniques such as principal component analysis, however, it requires a considerably less spectra to build a representative model and is suitable for comparing Raman spectra, having a noise other than the Gaussian one. The paper shows the prospects of the algorithm for creating a spectral library and solving the problem of transferring Raman libraries to a large number of spectrometers of the same type.
dc.relation.ispartofseries Journal of Raman Spectroscopy
dc.subject model transfer
dc.subject normalized relative error distribution analysis
dc.subject Pearson residuals
dc.subject Raman spectroscopy
dc.subject screening
dc.title Application of the normalized relative error distribution analysis for non-destructive quality control of drugs by Raman spectroscopy
dc.type Article
dc.relation.ispartofseries-issue 10
dc.relation.ispartofseries-volume 50
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 1614
dc.source.id SCOPUS03770486-2019-50-10-SID85070529586


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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