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Contractile activity-specific transcriptome response to acute endurance exercise and training in human skeletal muscle

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dc.contributor.author Popov X.
dc.contributor.author Makhnovskii P.
dc.contributor.author Shagimardanova E.
dc.contributor.author Gazizova G.
dc.contributor.author Lysenko E.
dc.contributor.author Gusev O.
dc.contributor.author Vinogradova O.
dc.date.accessioned 2020-01-15T21:17:17Z
dc.date.available 2020-01-15T21:17:17Z
dc.date.issued 2019
dc.identifier.issn 0193-1849
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/155537
dc.description.abstract © 2019 the American Physiological Society. Reduction in daily activity leads to dramatic metabolic disorders, while regular aerobic exercise training is effective for preventing this problem. The purpose of this study was to identify genes that are directly related to contractile activity in human skeletal muscle, regardless of the level of fitness. Transcriptome changes after the one-legged knee extension exercise in exercised and contralateral nonexercised vastus lateralis muscle of seven men were evaluated by RNA-seq. Transcriptome change at baseline after 2 mo of aerobic training (5/wk, 1 h/day) was evaluated as well. Postexercise changes in the transcriptome of exercised muscle were associated with different factors, including circadian oscillations. To reveal transcriptome response specific for endurance-like contractile activity, differentially expressed genes between exercised and nonexercised muscle were evaluated at 1 and 4 h after the one-legged exercise. The contractile activity-specific transcriptome responses were associated only with an increase in gene expression and were regulated mainly by CREB/ATF/AP1-, MYC/MAX-, and E2F-related transcription factors. Endurance training-induced changes (an increase or decrease) in the transcriptome at baseline were more pronounced than transcriptome responses specific for acute contractile activity. Changes after training were associated with widely different biological processes than those after acute exercise and were regulated by different transcription factors (IRF- and STAT-related factors). In conclusion, adaptation to regular exercise is associated not only with a transient (over several hours) increase in expression of many contractile activity-specific genes, but also with a pronounced change (an increase or decrease) in expression of a large number of genes under baseline conditions.
dc.relation.ispartofseries American Journal of Physiology - Endocrinology and Metabolism
dc.subject Aerobic exercise
dc.subject Contractile activity-specific transcriptome
dc.subject RNA sequencing
dc.subject Skeletal muscle
dc.subject Transcription factors
dc.title Contractile activity-specific transcriptome response to acute endurance exercise and training in human skeletal muscle
dc.type Article
dc.relation.ispartofseries-issue 4
dc.relation.ispartofseries-volume 316
dc.collection Публикации сотрудников КФУ
dc.relation.startpage E605
dc.source.id SCOPUS01931849-2019-316-4-SID85064221628

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  • Публикации сотрудников КФУ Scopus [22633]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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