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Cytocompatibility and uptake of polycations-modified halloysite clay nanotubes

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dc.contributor.author Tarasova E.
dc.contributor.author Naumenko E.
dc.contributor.author Rozhina E.
dc.contributor.author Akhatova F.
dc.contributor.author Fakhrullin R.
dc.date.accessioned 2020-01-15T21:17:08Z
dc.date.available 2020-01-15T21:17:08Z
dc.date.issued 2019
dc.identifier.issn 0169-1317
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/155518
dc.description.abstract © 2018 Elsevier B.V. The increasing use of clay-based polymer composite materials in industry and biomedicine stimulates the investigation of cellular uptake and toxicity of polymer\clay composites. In particular, halloysite nanotubes have become a promising material for a number of applications. Among other polymers, cationic polyelectrolytes have been employed in numerous studies as halloysite surface modifiers, without paying the proper attention to their toxicity. In this study we report our results on cytocompatibility and uptake of polycations-coated halloysite nanotubes. Adsorption of polycations onto clay nanotubes was investigated using microscopy and dynamic light scattering. We investigated cellular distribution and biological effects of halloysite surface-modified with poly(ethylenimine), poly(diallyldimethyl-ammonium) and poly (allylamine). We have employed a set of biological methods, such as microscopy (dark-field, electron and atomic force) and enzymatic tests to assay the toxicity of polycations-coated halloysite, using A549 human endothelial carcinoma cells in 2D and 3D cultures as the biological model. We found that polycations adsorbed onto halloysite surfaces significantly increase the otherwise low toxicity of pristine clay nanotubes, inducing cellular and nuclear defects.
dc.relation.ispartofseries Applied Clay Science
dc.subject Cellular uptake
dc.subject Cytotoxicity
dc.subject Halloysite nanotubes (Hal)
dc.subject Layer-by-Layer assembly
dc.subject Polyelectrolytes
dc.title Cytocompatibility and uptake of polycations-modified halloysite clay nanotubes
dc.type Article
dc.relation.ispartofseries-volume 169
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 21
dc.source.id SCOPUS01691317-2019-169-SID85058683225


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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