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Tumor Cell Behavior in Porous Hydrogels: Effect of Application Technique and Doxorubicin Treatment

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dc.contributor.author Zoughaib M.
dc.contributor.author Luong D.
dc.contributor.author Siraeva Z.
dc.contributor.author Yergeshov A.
dc.contributor.author Salikhova T.
dc.contributor.author Kuznetsova S.
dc.contributor.author Kiyamova R.
dc.contributor.author Abdullin T.
dc.date.accessioned 2020-01-15T20:52:25Z
dc.date.available 2020-01-15T20:52:25Z
dc.date.issued 2019
dc.identifier.issn 0007-4888
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/155484
dc.description.abstract © 2019, Springer Science+Business Media, LLC, part of Springer Nature. The effect of porosity on diffusion characteristics of scaffolds and invasive capacity of MCF-7 and PC-3 tumor cells was studied for gelatin hydrogels. According to MTS test results, the efficiency of population of a macroporous cryogel by cells applied by different techniques increased in the following order: migration from the monolayer<surface adhesion<<injection. Tumor cells in the cryogel differed by the migration and aggregation activity; injection route ensured a more uniform and dense population. In the cryogel-based culture, the cytotoxic effect of doxorubicin was 3-lower than in monolayer culture, which can be explained by supporting effect of the scaffold on cell growth and clustering. The results are of interest for the creation of tumor models and grafts with controlled properties.
dc.relation.ispartofseries Bulletin of Experimental Biology and Medicine
dc.subject 3D models of tumors
dc.subject doxorubicin resistance
dc.subject porous hydrogels
dc.subject scaffold population and analysis
dc.subject tumor cells
dc.title Tumor Cell Behavior in Porous Hydrogels: Effect of Application Technique and Doxorubicin Treatment
dc.type Article
dc.relation.ispartofseries-issue 4
dc.relation.ispartofseries-volume 167
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 590
dc.source.id SCOPUS00074888-2019-167-4-SID85073968676


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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