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High-Throughput Platform for B-Cell Screening Based on Fluorescent Phage-Display Technology

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dc.contributor.author Lomakin Y.
dc.contributor.author Kaminskaya A.
dc.contributor.author Stepanov A.
dc.contributor.author Shmidt A.
dc.contributor.author Gabibov A.
dc.contributor.author Belogurov A.
dc.date.accessioned 2020-01-15T20:52:25Z
dc.date.available 2020-01-15T20:52:25Z
dc.date.issued 2019
dc.identifier.issn 0007-4888
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/155483
dc.description.abstract © 2019, Springer Science+Business Media, LLC, part of Springer Nature. A system for detection of malignantly transformed cells, including follicular lymphoma Bcells, was developed and experimentally validated. The system is based on the use of bacteriophages carrying exposed ligands for pathogenic B-cell receptors. The efficiency of binding to target cells is several times higher than in systems with chemically synthesized biotinylated peptides. The new method is proposed as a noninvasive diagnostic test for mapping B-cell lymphoma and for determining the specificity of B-cell receptors and high-throughput combinatorial selection of various repertories of B cells.
dc.relation.ispartofseries Bulletin of Experimental Biology and Medicine
dc.subject B-cell receptor
dc.subject flow cytofluorometry
dc.subject follicular lymphoma
dc.subject M13K07 bacteriophage
dc.subject phage display
dc.title High-Throughput Platform for B-Cell Screening Based on Fluorescent Phage-Display Technology
dc.type Article
dc.relation.ispartofseries-issue 4
dc.relation.ispartofseries-volume 167
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 446
dc.source.id SCOPUS00074888-2019-167-4-SID85073924963


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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