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Effect of If Current Blockade on Newborn Rat Heart Isolated According to Langendorff

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dc.contributor.author Ziyatdinova N.
dc.contributor.author Kuptsova A.
dc.contributor.author Faskhutdinov L.
dc.contributor.author Galieva A.
dc.contributor.author Zefirov A.
dc.contributor.author Zefirov T.
dc.date.accessioned 2020-01-15T20:52:24Z
dc.date.available 2020-01-15T20:52:24Z
dc.date.issued 2019
dc.identifier.issn 0007-4888
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/155482
dc.description.abstract © 2019, Springer Science+Business Media, LLC, part of Springer Nature. The study examined the effects of hyperpolarization-activated funny current (If) on HR and coronary flow in Langendorff-isolated hearts from newborn rats. Blockade of If current with ZD7288 changed the examined cardiac parameters. The blocker in a concentration of 10—9 M decreased HR by 26.8% (p≤0.05). In concentrations 10—8, 10—7, 10—6, and 10—5 M ZD7288 produced minor differently directed effects. In a concentration of 10—5 M, ZD7288 reduced coronary flow in the isolated heart (p≤0.01). In other concentrations, the blocker produced no significant effects on coronary flow.
dc.relation.ispartofseries Bulletin of Experimental Biology and Medicine
dc.subject chronotropy
dc.subject coronary flow
dc.subject hyperpolarization-activated current
dc.subject isolated heart
dc.subject rat
dc.title Effect of If Current Blockade on Newborn Rat Heart Isolated According to Langendorff
dc.type Article
dc.relation.ispartofseries-issue 4
dc.relation.ispartofseries-volume 167
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 424
dc.source.id SCOPUS00074888-2019-167-4-SID85073814020


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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