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Effect of If Current Blockade on Newborn Rat Heart Isolated According to Langendorff
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| dc.contributor.author | Ziyatdinova N. | |
| dc.contributor.author | Kuptsova A. | |
| dc.contributor.author | Faskhutdinov L. | |
| dc.contributor.author | Galieva A. | |
| dc.contributor.author | Zefirov A. | |
| dc.contributor.author | Zefirov T. | |
| dc.date.accessioned | 2020-01-15T20:52:24Z | |
| dc.date.available | 2020-01-15T20:52:24Z | |
| dc.date.issued | 2019 | |
| dc.identifier.issn | 0007-4888 | |
| dc.identifier.uri | https://dspace.kpfu.ru/xmlui/handle/net/155482 | |
| dc.description.abstract | © 2019, Springer Science+Business Media, LLC, part of Springer Nature. The study examined the effects of hyperpolarization-activated funny current (If) on HR and coronary flow in Langendorff-isolated hearts from newborn rats. Blockade of If current with ZD7288 changed the examined cardiac parameters. The blocker in a concentration of 10—9 M decreased HR by 26.8% (p≤0.05). In concentrations 10—8, 10—7, 10—6, and 10—5 M ZD7288 produced minor differently directed effects. In a concentration of 10—5 M, ZD7288 reduced coronary flow in the isolated heart (p≤0.01). In other concentrations, the blocker produced no significant effects on coronary flow. | |
| dc.relation.ispartofseries | Bulletin of Experimental Biology and Medicine | |
| dc.subject | chronotropy | |
| dc.subject | coronary flow | |
| dc.subject | hyperpolarization-activated current | |
| dc.subject | isolated heart | |
| dc.subject | rat | |
| dc.title | Effect of If Current Blockade on Newborn Rat Heart Isolated According to Langendorff | |
| dc.type | Article | |
| dc.relation.ispartofseries-issue | 4 | |
| dc.relation.ispartofseries-volume | 167 | |
| dc.collection | Публикации сотрудников КФУ | |
| dc.relation.startpage | 424 | |
| dc.source.id | SCOPUS00074888-2019-167-4-SID85073814020 |
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Публикации сотрудников КФУ Scopus [24551]
Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.