Электронный архив

The Thermal Sensitivity of Purinergic Modulation of Contractile Activity of Locomotor and Respiratory Muscles in Mice

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dc.contributor.author Khairullin A.
dc.contributor.author Teplov A.
dc.contributor.author Grishin S.
dc.contributor.author Farkhutdinov A.
dc.contributor.author Ziganshin A.
dc.date.accessioned 2020-01-15T20:52:21Z
dc.date.available 2020-01-15T20:52:21Z
dc.date.issued 2019
dc.identifier.issn 0006-3509
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/155477
dc.description.abstract © 2019, Pleiades Publishing, Inc. Abstract—We have previously demonstrated that hypothermia significantly modulates the effect of ATP on the contractile activities of various types of rodent locomotor muscles. The aim of this study was to compare the effects of ATP on contraction of mouse locomotor (m. soleus) and respiratory (m. Diafragma) muscles at normal and low temperatures. It has been found that a decrease in the ambient temperature to 22°C is associated with a decrease in the force of muscle contraction (m. Diafragma) induced by electrical stimulation and carbachol, as well as with an increase in the contractile force of m. soleus. The potentiating effects of ATP in these muscles are preserved even in response to temperature reduction, but they are enhanced only in carbachol-induced contractions, thus indicating a postsynaptic localization of a thermal sensitive element in purine modulation. The characteristic features of ATP release modulation with the predominant postsynaptic thermal sensitive link in different motor units in hypothermia in mice may underlie the adaptive mechanisms of this small rodent.
dc.relation.ispartofseries Biophysics (Russian Federation)
dc.subject ATP
dc.subject Keywords: hypothermia
dc.subject locomotor and respiratory muscles
dc.subject P2 receptors
dc.subject suramin
dc.subject synapse
dc.title The Thermal Sensitivity of Purinergic Modulation of Contractile Activity of Locomotor and Respiratory Muscles in Mice
dc.type Article
dc.relation.ispartofseries-issue 5
dc.relation.ispartofseries-volume 64
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 812
dc.source.id SCOPUS00063509-2019-64-5-SID85076499190


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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