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Small-angle neutron and X-ray scattering analysis of the supramolecular organization of rhodopsin in photoreceptor membrane

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dc.contributor.author Feldman T.
dc.contributor.author Ivankov O.
dc.contributor.author Kuklin A.
dc.contributor.author Murugova T.
dc.contributor.author Yakovleva M.
dc.contributor.author Smitienko O.
dc.contributor.author Kolchugina I.
dc.contributor.author Round A.
dc.contributor.author Gordeliy V.
dc.contributor.author Belushkin A.
dc.contributor.author Ostrovsky M.
dc.date.accessioned 2020-01-15T20:52:19Z
dc.date.available 2020-01-15T20:52:19Z
dc.date.issued 2019
dc.identifier.issn 0005-2736
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/155473
dc.description.abstract © 2019 Elsevier B.V. The supramolecular organization of the visual pigment rhodopsin in the photoreceptor membrane remains contentious. Specifically, whether this G protein-coupled receptor functions as a monomer or dimer remains unknown, as does the presence or absence of ordered packing of rhodopsin molecules in the photoreceptor membrane. Completely opposite opinions have been expressed on both issues. Herein, using small-angle neutron and X-ray scattering approaches, we performed a comparative analysis of the structural characteristics of the photoreceptor membrane samples in buffer, both in the outer segment of photoreceptor cells, and in the free photoreceptor disks. The average distance between the centers of two neighboring rhodopsin molecules was found to be ~5.8 nm in both cases. The results indicate an unusually high packing density of rhodopsin molecules in the photoreceptor membrane, but molecules appear to be randomly distributed in the membrane without any regular ordering.
dc.relation.ispartofseries Biochimica et Biophysica Acta - Biomembranes
dc.subject Oligomerization
dc.subject Photoreceptor membrane
dc.subject Rhodopsin
dc.subject SANS
dc.subject SAXS
dc.subject Supramolecular organization
dc.title Small-angle neutron and X-ray scattering analysis of the supramolecular organization of rhodopsin in photoreceptor membrane
dc.type Article
dc.relation.ispartofseries-issue 10
dc.relation.ispartofseries-volume 1861
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS00052736-2019-1861-10-SID85066621928


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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