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OMICS technologies in reproductive medicine: Assessment of quality of oocytes and embryos

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dc.date.accessioned 2019-01-22T20:58:12Z
dc.date.available 2019-01-22T20:58:12Z
dc.date.issued 2018
dc.identifier.issn 2313-1829
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/149665
dc.description.abstract © 2018 Human Stem Cell Institute. All rights reserved. One of the main factors of success of the procedure art (assisted reproductive technology) is the selection of the most high-quality gametes for further manipulation and obtaining a viable embryo for implantation. The majority of modern techniques based on morphokinetic predictors of quality (i. e. assessment of embryo morphology and rate of division of the blastomeres), which allowed to achieve some success in increasing the percentage of successful pregnancies and reduce the number of multiple pregnancies, but their accuracy is currently insufficient. Thus, the development of objective, reliable, fast and affordable test systems to determine the quality of oocytes and the development potential of the embryo one of the challenges of reproductive medicine. The purpose of this review was to describe the advantages and limitations obecnych technologies, the application of which will allow to deepen our understanding of the physiology of the embryo, as well as set criteria for non-invasive selection of gametes and embryos. In this regard, recently in assisted reproduction are applied the studies of genomic, proteomic, transcript, and metabolomic profiles of oocytes, granulosa and Cumulus cells, embryos, of conditioned media.
dc.relation.ispartofseries Genes and Cells
dc.subject Blastocyst
dc.subject Embryo
dc.subject Genomics
dc.subject Metabolome
dc.subject Proteome
dc.subject Secretome
dc.subject Transcriptome
dc.title OMICS technologies in reproductive medicine: Assessment of quality of oocytes and embryos
dc.type Review
dc.relation.ispartofseries-issue 1
dc.relation.ispartofseries-volume 13
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 35
dc.source.id SCOPUS23131829-2018-13-1-SID85049143010

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  • Публикации сотрудников КФУ Scopus [22633]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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