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Synthesis and Properties of Hydrazine-Embedded Biphenothiazines and Application of Hydrazine-Embedded Heterocyclic Compounds to Fluorescence Cell Imaging

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dc.contributor.author Shindo Y.
dc.contributor.author Nomura S.
dc.contributor.author Saikawa Y.
dc.contributor.author Nakata M.
dc.contributor.author Tanaka K.
dc.contributor.author Hanaya K.
dc.contributor.author Sugai T.
dc.contributor.author Higashibayashi S.
dc.date.accessioned 2019-01-22T20:57:34Z
dc.date.available 2019-01-22T20:57:34Z
dc.date.issued 2018
dc.identifier.issn 2193-5807
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/149619
dc.description.abstract © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Hydrazine-embedded unsubstituted butterfly-shaped biphenothiazine and its sulfoxides were synthesized by dimerization of 1,9-dibromophenothiazine, which was prepared by realizing selective debromination at the 3,7-positions of 1,3,7,9-tetrabromophenothiazine. cis/trans-Biphenothiazine sulfoxide was selectively prepared by changing the oxidation temperature to control the inversion rate of the butterfly shape of the intermediate. Their butterfly-shapes, conformations, photophysical properties (UV-vis absorption, fluorescence), and redox properties were elucidated by X-ray analysis, DFT calculations, spectral and electrochemical measurements. Fluorescent hydrazine-embedded biphenothiazine sulfoxides and bicarbazoles were applied to cell imaging of HeLa cells. The bicarbazoles exhibited high fluorescence signals in the cells with low toxicity.
dc.relation.ispartofseries Asian Journal of Organic Chemistry
dc.subject carbazoles
dc.subject fluorescence
dc.subject hydrazines
dc.subject imaging agents
dc.subject phenothiazines
dc.title Synthesis and Properties of Hydrazine-Embedded Biphenothiazines and Application of Hydrazine-Embedded Heterocyclic Compounds to Fluorescence Cell Imaging
dc.type Article
dc.relation.ispartofseries-issue 9
dc.relation.ispartofseries-volume 7
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 1797
dc.source.id SCOPUS21935807-2018-7-9-SID85053062541


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  • Публикации сотрудников КФУ Scopus [22633]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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