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Effect of Curcumin and Gliotoxin on Rat Liver Myofibroblast Culture

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dc.contributor.author Shafigullina A.
dc.contributor.author Mijanovic O.
dc.contributor.author Prottoy R.
dc.contributor.author Zhuravleva M.
dc.contributor.author Gomzikova M.
dc.contributor.author Gumerova A.
dc.contributor.author Rizvanov A.
dc.contributor.author Kiyasov A.
dc.date.accessioned 2019-01-22T20:57:26Z
dc.date.available 2019-01-22T20:57:26Z
dc.date.issued 2018
dc.identifier.issn 2191-1630
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/149605
dc.description.abstract © 2017, Springer Science+Business Media, LLC, part of Springer Nature. Since the 1990s, when it was demonstrated by Hammel and others that liver fibrosis is reversible, researchers and physicians actively search for new antifibrotic therapies. In recent years, knowledge of liver fibrosis pathophysiology has greatly advanced and new cellular and molecular mechanisms were described. The cells that determine extracellular matrix components distribution are myofibroblasts, but their origin is diverse. They can be activated hepatic stellate cells (HSCs), portal fibroblasts (PF), or circulating mesenchymal stem cells of the bone marrow. Among large number of substrates to inhibit activation, to inhibit proliferation of myofibroblasts, and to induce their apoptosis we, chose curcumin and gliotoxin. Primarily, in the current work, we optimized the explantation culture method for isolation of hepatic myofibroblasts and received two different cultures—myofibroblasts of HSC and PF origin. Exposition of 50 μM curcumin and 0.1 μM gliotoxin was the most optimal; we observed suppression of hepatic myofibroblast activation and inhibition of their proliferation. These results extend the current knowledge of the cells within the liver fibrogenic populations and prove inhibitory influence of biologically active substances (curcumin and gliotoxin) on portal myofibroblasts.
dc.relation.ispartofseries BioNanoScience
dc.subject Apoptosis
dc.subject Curcumin
dc.subject Gliotoxin
dc.subject Hepatic stellate cells
dc.subject Liver fibrosis
dc.subject Myofibroblasts
dc.subject Portal fibroblasts
dc.title Effect of Curcumin and Gliotoxin on Rat Liver Myofibroblast Culture
dc.type Article
dc.relation.ispartofseries-issue 2
dc.relation.ispartofseries-volume 8
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 522
dc.source.id SCOPUS21911630-2018-8-2-SID85048242309


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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