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Intravenous Transplantation of Human Umbilical Cord Blood Mononuclear Cells Overexpressing Nerve Growth Factor Improves Spatial Memory in APP/PS1 Transgenic Mice with a Model of Alzheimer’s Disease

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dc.contributor.author Kaligin M.
dc.contributor.author Mukhamedshina Y.
dc.contributor.author Rizvanov A.
dc.contributor.author Zefirov A.
dc.contributor.author Islamov R.
dc.date.accessioned 2019-01-22T20:57:11Z
dc.date.available 2019-01-22T20:57:11Z
dc.date.issued 2018
dc.identifier.issn 2191-1630
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/149584
dc.description.abstract © 2017, Springer Science+Business Media, LLC, part of Springer Nature. Alzheimer’s disease is a progressive incurable neurodegenerative disease manifested by dementia and other cognitive disorders. Gene-cell therapy is one of the most promising trends in the development of treatment for Alzheimer’s disease. The study was aimed to evaluate the therapeutic potential of intravenous transplantation of human umbilical cord blood mononuclear cells (UCBMCs) transduced with adenoviral vectors overexpressing nerve growth factor (NGF) for the treatment of Alzheimer’s disease in an APP/PS1 transgenic mice model. The transplantation of NGF-expressing UCBMCs was found to improve spatial memory and decrease anxiety in APP/PS1 mice. Grafted cells and their expression of NGF were detected in the cortex and hippocampus of transgenic mice in the period up to 90 days after transplantation. Thus, gene-cell therapy based on the use of NGF-overexpressing UCBMCs is a promising approach for the development of Alzheimer’s disease treatments.
dc.relation.ispartofseries BioNanoScience
dc.subject Alzheimer’s disease
dc.subject APP/PS1 transgenic mice
dc.subject Gene-cell therapy
dc.subject Nerve growth factor
dc.subject Stem cells
dc.subject Umbilical cord blood mononuclear cells
dc.title Intravenous Transplantation of Human Umbilical Cord Blood Mononuclear Cells Overexpressing Nerve Growth Factor Improves Spatial Memory in APP/PS1 Transgenic Mice with a Model of Alzheimer’s Disease
dc.type Article
dc.relation.ispartofseries-issue 1
dc.relation.ispartofseries-volume 8
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 473
dc.source.id SCOPUS21911630-2018-8-1-SID85044366548


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  • Публикации сотрудников КФУ Scopus [22633]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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