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ATP reduces the entry of calcium ions into the nerve ending by Blocking L-type calcium channels

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dc.date.accessioned 2019-01-22T20:56:39Z
dc.date.available 2019-01-22T20:56:39Z
dc.date.issued 2018
dc.identifier.issn 2075-8251
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/149543
dc.description.abstract © 2018 Park-media, Ltd. At neuromuscular junctions, ATP inhibits both the evoked and spontaneous acetylcholine release and inward calcium current operating via presynaptic P2Y receptors. It was shown in experiments with the frog neuromuscular synapse using specific calcium-sensitive dye Oregon Green Bapta 1 that exogenous ATP reduces the amplitude of calcium transient, which reflects the changes in the entry of calcium ions in response to the nerve pulse. The depressing effect of ATP on the transient was prevented by suramin, the blocker of P2 receptors. Nitrendipine, a specific blocker of L-type calcium channels, per se decreased the calcium transient amplitude and significantly attenuated the effect of ATP on the calcium signal. Contrariwise, the preliminary application of ATP to the neuromuscular junction completely eliminated the depressing effect of nitrendipine on the calcium response. The obtained data suggest that an essential component in the inhibitory action of ATP on the calcium transient amplitude is provided by reduction of the entry of calcium ions into a frog nerve ending via L-type voltage-gated calcium channels.
dc.relation.ispartofseries Acta Naturae
dc.subject ATP
dc.subject Calcium channels
dc.subject Calcium transient
dc.subject Neuromuscular junction
dc.title ATP reduces the entry of calcium ions into the nerve ending by Blocking L-type calcium channels
dc.type Article
dc.relation.ispartofseries-issue 2
dc.relation.ispartofseries-volume 10
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 93
dc.source.id SCOPUS20758251-2018-10-2-SID85054091443


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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