Gene-Activated Bone Substitute Based on Octacalcium Phosphate and Doped with Magnesium Ions

dc.date.accessioned	2019-01-22T20:56:37Z
dc.date.available	2019-01-22T20:56:37Z
dc.date.issued	2018
dc.identifier.issn	2075-1133
dc.identifier.uri	https://dspace.kpfu.ru/xmlui/handle/net/149540
dc.description.abstract	© 2018, Pleiades Publishing, Ltd. This work is aimed at the optimization of the phase composition, surface morphology, and microstructure of matrices based on octacalcium phosphate (OCP) in order to increase the maximum dose and dosing accuracy of immobilized nucleic acids (NAs). It is determined that the modification of the scaffold with magnesium leads to a 1.4-fold increase in binding of plasmid DNA, which can further be used for the fabrication of medical products with the specified high concentration of biologically active NAs. Preliminary in vitro evaluation shows that the addition of magnesium to OCP regulates metabolic activity of HEK-293FT cell lines.
dc.relation.ispartofseries	Inorganic Materials: Applied Research
dc.subject	bone substitute
dc.subject	calcium phosphates
dc.subject	gene-activated material
dc.subject	genes
dc.subject	nucleic acids
dc.subject	octacalcium phosphate
dc.title	Gene-Activated Bone Substitute Based on Octacalcium Phosphate and Doped with Magnesium Ions
dc.type	Article
dc.relation.ispartofseries-issue	1
dc.relation.ispartofseries-volume	9
dc.collection	Публикации сотрудников КФУ
dc.relation.startpage	70
dc.source.id	SCOPUS20751133-2018-9-1-SID85042666338

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Публикации сотрудников КФУ Scopus [24551]
Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.