Kazan Federal University Digital Repository

Emerging role of (endo)cannabinoids in migraine

Show simple item record

dc.contributor.author Leimuranta P.
dc.contributor.author Khiroug L.
dc.contributor.author Giniatullin R.
dc.date.accessioned 2019-01-22T20:55:28Z
dc.date.available 2019-01-22T20:55:28Z
dc.date.issued 2018
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/149438
dc.description.abstract © 2018 Leimuranta, Khiroug and Giniatullin. In this mini-review, we summarize recent discoveries and present new hypotheses on the role of cannabinoids in controlling trigeminal nociceptive system underlying migraine pain. Individual sections of this review cover key aspects of this topic, such as: (i) the current knowledge on the endocannabinoid system (ECS) with emphasis on expression of its components in migraine related structures; (ii) distinguishing peripheral from central site of action of cannabinoids, (iii) proposed mechanisms of migraine pain and control of nociceptive traffic by cannabinoids at the level of meninges and in brainstem, (iv) therapeutic targeting in migraine of monoacylglycerol lipase and fatty acid amide hydrolase, enzymes which control the level of endocannabinoids; (v) dual (possibly opposing) actions of cannabinoids via anti-nociceptive CB1 and CB2 and pro-nociceptive TRPV1 receptors. We explore the cannabinoid-mediated mechanisms in the frame of the Clinical Endocannabinoid Deficiency (CECD) hypothesis, which implies reduced tone of endocannabinoids in migraine patients. We further discuss the control of cortical excitability by cannabinoids via inhibition of cortical spreading depression (CSD) underlying the migraine aura. Finally, we present our view on perspectives of Cannabis-derived (extracted or synthetized marijuana components) or novel endocannabinoid therapeutics in migraine treatment.
dc.subject Cannabinoid receptor
dc.subject Cannabinoids
dc.subject CGRP
dc.subject Marijuana
dc.subject Migraine
dc.subject Nociception
dc.subject TRPV1
dc.title Emerging role of (endo)cannabinoids in migraine
dc.type Short Survey
dc.relation.ispartofseries-issue APR
dc.relation.ispartofseries-volume 9
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS-2018-9--SID85045872988

Files in this item

This item appears in the following Collection(s)

  • Публикации сотрудников КФУ Scopus [22633]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

Show simple item record

Search DSpace

Advanced Search


My Account