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Shape changes of erythrocytes during blood clot contraction and the structure of polyhedrocytes

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dc.contributor.author Tutwiler V.
dc.contributor.author Mukhitov A.
dc.contributor.author Peshkova A.
dc.contributor.author Le Minh G.
dc.contributor.author Khismatullin R.
dc.contributor.author Vicksman J.
dc.contributor.author Nagaswami C.
dc.contributor.author Litvinov R.
dc.contributor.author Weisel J.
dc.date.accessioned 2019-01-22T20:54:45Z
dc.date.available 2019-01-22T20:54:45Z
dc.date.issued 2018
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/149384
dc.description.abstract © 2018, The Author(s). Polyhedral erythrocytes, named polyhedrocytes, are formed in contracted blood clots and thrombi, as a result of compression by activated contractile platelets pulling on fibrin. This deformation was shown to be mechanical in nature and polyhedrocytes were characterized using light and electron microscopy. Through three-dimensional reconstruction, we quantified the geometry of biconcave, intermediate, and polyhedral erythrocytes within contracting blood clots. During compression, erythrocytes became less oblate and more prolate than the biconcave cells and largely corresponded to convex, irregular polyhedra with a total number of faces ranging from 10 to 16. Faces were polygons with 3 to 6 sides. The majority of the faces were quadrilaterals, though not all sides were straight and not all faces were flat. There were no changes in the surface area or volume. These results describe the gradual natural deformation of erythrocytes as a part of compaction into a tightly packed array that is an important but understudied component of mature blood clots and thrombi.
dc.title Shape changes of erythrocytes during blood clot contraction and the structure of polyhedrocytes
dc.type Article
dc.relation.ispartofseries-issue 1
dc.relation.ispartofseries-volume 8
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS-2018-8-1-SID85058724785


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  • Публикации сотрудников КФУ Scopus [22633]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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