Kazan Federal University Digital Repository

Influence of genetically modified human umbilical cord blood mononuclear cells on the expression of schwann cell molecular determinants in spinal cord injury

Show simple item record

dc.date.accessioned 2019-01-22T20:53:31Z
dc.date.available 2019-01-22T20:53:31Z
dc.date.issued 2018
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/149290
dc.description.abstract Copyright © 2018 L. R. Galieva et al. Spinal cord injury (SCI) unavoidably results in death of not only neurons but also glial cells. In particular, the death of oligodendrocytes leads to impaired nerve impulse conduction in intact axons. However, after SCI, the Schwann cells (SCs) are capable of migrating towards an area of injury and participating in the formation of functional myelin. In addition to SCI, cellbased therapy can influence the migration of SCs and the expression of their molecular determinants. In a number of cases, it can be explained by the ability of implanted cells to secrete neurotrophic factors (NTFs). Genetically modified stem and progenitor cells overexpressing NTFs have recently attracted special attention of researchers and are most promising for the purposes of regenerative medicine. Therefore, we have studied the effect of genetically modified human umbilical cord blood mononuclear cells on the expression of SC molecular determinants in SCI.
dc.title Influence of genetically modified human umbilical cord blood mononuclear cells on the expression of schwann cell molecular determinants in spinal cord injury
dc.type Article
dc.relation.ispartofseries-volume 2018
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS-2018-2018-SID85056115645


Files in this item

This item appears in the following Collection(s)

  • Публикации сотрудников КФУ Scopus [22633]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

Show simple item record

Search DSpace


Advanced Search

Browse

My Account