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Cancer immunology, bioinformatics and chemokine evidence link vaccines contaminated with animal proteins to autoimmune disease: A detailed look at Crohn’s disease and Vitiligo

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dc.contributor.author Arumugham V.
dc.contributor.author Trushin M.
dc.date.accessioned 2019-01-22T20:52:47Z
dc.date.available 2019-01-22T20:52:47Z
dc.date.issued 2018
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/149226
dc.description.abstract © 2018, Pharmainfo Publications. All rights reserved. Cancer research has demonstrated that immunization with homologous xenogeneic proteins (such as vaccines contaminated with animal proteins that resemble human proteins) results in autoimmunity. Bioinformatics analysis demonstrates that animal proteins have occasional amino acid differences compared to equivalent human proteins. For this purpose we used Uniprot and BLASTP. We found homology to human GP2 (Bos taurus 77%, Sus scrofa 76%, Cavia porcellus 72% Gallus gallus 43%), homology to human tyrosinase (Bos taurus 87%, Sus scrofa 90%, Cavia porcellus 85%, Gallus gallus 73%), homology to human GP100 (Bos taurus 77%, Sus scrofa 81%, Cavia porcellus 77%, Gallus gallus 42%) and highlight the occasional amino acid differences. Mutated human protein epitopes can be identical to animal protein derived epitopes. Low affinity self reactive T cells suited for detection of mutated human epitopes will be activated by animal derived epitopes. CD8+ T cells involved in numerous autoimmune disorders express the CCR4 skin homing receptor. This is evidence that the site of priming was the skin. This is consistent with subcutaneous or intramuscular injection of animal protein contaminated vaccines. The above findings add to the growing evidence of vaccines inducing autoimmune diseases. Autoantibody and autoreactive T cell levels can vary from person to person. Not everyone will develop overt disease. For every case of diagnosed autoimmune disease, there are numerous subclinical cases. These subclinical diseases could shave decades off your life. So “rare” diagnosed vaccine adverse events are the tip of the iceberg.
dc.subject Autoimmune disease
dc.subject Bioinformatics
dc.subject Cancer immunology
dc.subject Chemokine
dc.subject Vaccines contaminated
dc.title Cancer immunology, bioinformatics and chemokine evidence link vaccines contaminated with animal proteins to autoimmune disease: A detailed look at Crohn’s disease and Vitiligo
dc.type Article
dc.relation.ispartofseries-issue 8
dc.relation.ispartofseries-volume 10
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 2106
dc.source.id SCOPUS-2018-10-8-SID85052742133


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  • Публикации сотрудников КФУ Scopus [22633]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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