Obesity and functional state of kidney depends on VEGF polymorphism

Abstract

© 2018, Pharmainfo Publications. All rights reserved. The aim this study was to investigate the relationship of polymorphism VEGF gene to the functional state of kidneys in patients with various phenotypes of obesity. We examined 240 persons (mean age of 43.4±7.3), which were distributed in several groups. The first group included 90 patients with obesity with metabolic disorders. The second group was presented by 50 patients-they do not display signs of metabolic disorder. The control group was composed of healthy. We detected high levels of VEGF in blood and urine, A2, type IV collagen and predominance of minor C allele in group 1. In group 2, there were VEGF increase in blood and urine (at optimal values of GFR and A1). We detected a link between polymorphism of promoter region of-634 G/С with levels of SBP, GFR, A2, type IV collagen and increased expression of VEGF in blood and urine. The increase in VEGF in the urine reflects the activation of angiogenesis and endothelial dysfunction, aggravated during the development and progression of chronic kidney disease. In the group with obesity and hypertension, we detected an increase of VEGF level in urine, while maintaining the normal range of A and GFR. The distribution of genotypes in the region-634 G/C of VEGF gene revealed the associating carriage of the minor allele in the group 2. In the group 1, albuminuria 2 was associated with the CC variant of VEGF gene (-634 G/C).