Kazan Federal University Digital Repository

Tiny Rare-Earth Fluoride Nanoparticles Activate Tumour Cell Growth via Electrical Polar Interactions

Show simple item record

dc.contributor.author Semashko V.
dc.contributor.author Pudovkin M.
dc.contributor.author Cefalas A.
dc.contributor.author Zelenikhin P.
dc.contributor.author Gavriil V.
dc.contributor.author Nizamutdinov A.
dc.contributor.author Kollia Z.
dc.contributor.author Ferraro A.
dc.contributor.author Sarantopoulou E.
dc.date.accessioned 2019-01-22T20:51:07Z
dc.date.available 2019-01-22T20:51:07Z
dc.date.issued 2018
dc.identifier.issn 1931-7573
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/149096
dc.description.abstract © 2018, The Author(s). Localised extracellular interactions between nanoparticles and transmembrane signal receptors may well activate cancer cell growth. Herein, tiny LaF3 and PrF3 nanoparticles in DMEM+FBS suspensions stimulated tumour cell growth in three different human cell lines (A549, SW837 and MCF7). Size distribution of nanoparticles, activation of AKT and ERK signalling pathways and viability tests pointed to mechanical stimulation of ligand adhesion binding sites of integrins and EGFR via a synergistic action of an ensemble of tiny size nanoparticles (< 10 nm). While tiny size nanoparticles may be well associated with the activation of EGFR, integrin interplay with nanoparticles remains a multifaceted issue. A theoretical motif shows that, within the requisite pN force scale, each ligand adhesion binding site can be activated by a tiny size dielectric nanoparticle via electrical dipole interaction. The size of the active nanoparticle stayed specified by the amount of the surface charges on the ligand adhesion binding site and the nanoparticle, and also by the separating distance between them. The polar component of the electrical dipole force remained inversely proportional to the second power of nanoparticle’s size, evincing that only tiny size dielectric nanoparticles might stimulate cancer cell growth via electrical dipole interactions. The work contributes towards recognising different cytoskeletal stressing modes of cancer cells.
dc.relation.ispartofseries Nanoscale Research Letters
dc.subject Atomic force microscopy
dc.subject Biosurfaces
dc.subject Cancer and nanoparticles
dc.subject EGFR
dc.subject Electrical dipole interactions
dc.subject Integrins
dc.subject Mechanosensors
dc.subject Mechanotransducers
dc.subject Nanotechnology
dc.subject Physics of cancer
dc.subject Tumorigenesis
dc.title Tiny Rare-Earth Fluoride Nanoparticles Activate Tumour Cell Growth via Electrical Polar Interactions
dc.type Article
dc.relation.ispartofseries-volume 13
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS19317573-2018-13-SID85057947649


Files in this item

This item appears in the following Collection(s)

  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics