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Evaluation of mutagenic and antimutagenic potential of stem bark aqueous extracts of eight trees by the bacterial reverse mutation assay

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dc.date.accessioned 2019-01-22T20:50:21Z
dc.date.available 2019-01-22T20:50:21Z
dc.date.issued 2018
dc.identifier.issn 1811-0932
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/149035
dc.description.abstract © 2018 LLC Eco-Vector. All Rights Reserved. Stem bark aqueous extracts of eight woody plants Brachychiton populneus, Ceiba pentandra, Bombax malabaricum, Chorisia speciosa, Albizia lebbeck, Bauhinia variegata, Kigelia africana and Pinus halepensis were tested for their mutagenic and antimutagenic potential in the Ames test with Salmonella typhimurium strains TA98 and TA100. The aqueous extracts were neither toxic nor mutagenic in S. typhimurium tester strains. All of the tested extracts showed detectable antimutagenic effect towards the direct acting mutagens 2-nitrofluorene (2-NF) in TA98 as well as sodium azide in TA100. The extract from Kigelia africana was the most effective in reducing the mutagenicity caused by the direct mutagen 2-NF in the TA98 with 85.42 % inhibition rate. A. lebbeck stem bark extract demonstrated the highest antimutagenic activity reducing the base substitution mutations rate for strain TA100 by 94.66% in preincu-bation assay. The results obtained showed that the stem bark aqueous extracts tested can protect cells against induced gene mutations.
dc.relation.ispartofseries Ecological Genetics
dc.subject Ames test
dc.subject Antimutagenicity
dc.subject Medicinal plants
dc.subject Mutagenicity
dc.subject Salmonella typhimurium strains
dc.subject Stem bark extracts
dc.title Evaluation of mutagenic and antimutagenic potential of stem bark aqueous extracts of eight trees by the bacterial reverse mutation assay
dc.type Article
dc.relation.ispartofseries-issue 3
dc.relation.ispartofseries-volume 16
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 55
dc.source.id SCOPUS18110932-2018-16-3-SID85056849342


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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