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Self-assembly of Gd<sup>3+</sup>-bound keplerate polyanions into nanoparticles as a route for the synthesis of positive MRI contrast agents. Impact of the structure on the magnetic relaxivity

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dc.contributor.author Elistratova J.
dc.contributor.author Akhmadeev B.
dc.contributor.author Korenev V.
dc.contributor.author Sokolov M.
dc.contributor.author Nizameev I.
dc.contributor.author Gubaidullin A.
dc.contributor.author Voloshina A.
dc.contributor.author Mustafina A.
dc.date.accessioned 2019-01-22T20:48:03Z
dc.date.available 2019-01-22T20:48:03Z
dc.date.issued 2018
dc.identifier.issn 1744-683X
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/148834
dc.description.abstract © The Royal Society of Chemistry. The present work introduces Gd3+ complexes with giant keplerate polyanions as a promising basis for MRI contrast agents. The impact of Gd3+ binding with different building blocks of keplerates on the magnetic relaxivity of the complexes is revealed by comparative study of the keplerates [{Mo6O21}12{Mo2O4(OAc)}30]42−, [{Mo6O21}12{Mo2O4(HPO4)}30]72−, and [{Mo6O21}12{Mo2O2S2(OAc)}30]42−. Unprecedentedly high longitudinal and transverse relaxivity values (up to 250 and 300 mM−1 s−1 correspondingly) are achieved for the keplerates possessing edl{Mo2O4(OAc)} and {Mo2O4(HPO42−)} moieties under their 1 : 1 complex formation with Gd3+. The transformation of the external pores from Mo9O9 to Mo9O6S3 in the {Mo2O2S2(OAc)}-keplerate and an increase in the Gd3+-to-keplerate ratio are the factors that decrease the relaxivity. The rapid degradation of the free keplerates in aqueous solutions restricts the use of the Gd3+-bound keplerates with 1 : 1 stoichiometry as MRI contrast agents. In this work, the optimized stoichiometry of the complexes, their self-assembly into ultra-small nanoparticles and their hydrophilic coating by a triblock copolymer are highlighted as tools for increasing both the colloid and chemical stability of the keplerate complexes. Optimal keplerate compositions have been identified to achieve a compromise of low cytotoxicity and high stability; these Gd3+-bound keplerates exhibit longitudinal and transverse relaxivity values (95 and 114 mM−1 s−1, respectively), well within the region of interest for MRI techniques.
dc.relation.ispartofseries Soft Matter
dc.title Self-assembly of Gd<sup>3+</sup>-bound keplerate polyanions into nanoparticles as a route for the synthesis of positive MRI contrast agents. Impact of the structure on the magnetic relaxivity
dc.type Article
dc.relation.ispartofseries-issue 38
dc.relation.ispartofseries-volume 14
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 7916
dc.source.id SCOPUS1744683X-2018-14-38-SID85054378543


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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