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Somatic Accumulation of GluA1-AMPA Receptors Leads to Selective Cognitive Impairments in Mice

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dc.contributor.author Bannerman D.
dc.contributor.author Borchardt T.
dc.contributor.author Jensen V.
dc.contributor.author Rozov A.
dc.contributor.author Haj-Yasein N.
dc.contributor.author Burnashev N.
dc.contributor.author Zamanillo D.
dc.contributor.author Bus T.
dc.contributor.author Grube I.
dc.contributor.author Adelmann G.
dc.contributor.author Rawlins J.
dc.contributor.author Sprengel R.
dc.date.accessioned 2019-01-22T20:46:35Z
dc.date.available 2019-01-22T20:46:35Z
dc.date.issued 2018
dc.identifier.issn 1662-5099
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/148718
dc.description.abstract © 2018 Bannerman, Borchardt, Jensen, Rozov, Haj-Yasein, Burnashev, Zamanillo, Bus, Grube, Adelmann, Rawlins and Sprengel. The GluA1 subunit of the L-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) plays a crucial, but highly selective, role in cognitive function. Here we analyzed AMPAR expression, AMPAR distribution and spatial learning in mice (Gria1R/R), expressing the “trafficking compromised” GluA1(Q600R) point mutation. Our analysis revealed somatic accumulation and reduction of GluA1(Q600R) and GluA2, but only slightly reduced CA1 synaptic localization in hippocampi of adult Gria1R/R mice. These immunohistological changes were accompanied by a strong reduction of somatic AMPAR currents in CA1, and a reduction of plasticity (short-term and long-term potentiation, STP and LTP, respectively) in the CA1 subfield following tetanic and theta-burst stimulation. Nevertheless, spatial reference memory acquisition in the Morris water-maze and on an appetitive Y-maze task was unaffected in Gria1R/R mice. In contrast, spatial working/short-term memory during both spontaneous and rewarded alternation tasks was dramatically impaired. These findings identify the GluA1(Q600R) mutation as a loss of function mutation that provides independent evidence for the selective role of GluA1 in the expression of short-term memory.
dc.relation.ispartofseries Frontiers in Molecular Neuroscience
dc.subject AMPA receptors
dc.subject GluA1
dc.subject Long-term potentiation
dc.subject Morris water-maze
dc.subject RNA-editing
dc.subject Spatial memory
dc.subject Spatial working memory
dc.title Somatic Accumulation of GluA1-AMPA Receptors Leads to Selective Cognitive Impairments in Mice
dc.type Article
dc.relation.ispartofseries-volume 11
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS16625099-2018-11-SID85054790413


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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