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Expanding the Applicability of the Metal Labeling of Biomolecules by the RIKEN Click Reaction: A Case Study with Gallium-68 Positron Emission Tomography
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| dc.contributor.author | Nakamoto Y. | |
| dc.contributor.author | Pradipta A. | |
| dc.contributor.author | Mukai H. | |
| dc.contributor.author | Zouda M. | |
| dc.contributor.author | Watanabe Y. | |
| dc.contributor.author | Kurbangalieva A. | |
| dc.contributor.author | Ahmadi P. | |
| dc.contributor.author | Manabe Y. | |
| dc.contributor.author | Fukase K. | |
| dc.contributor.author | Tanaka K. | |
| dc.date.accessioned | 2019-01-22T20:45:53Z | |
| dc.date.available | 2019-01-22T20:45:53Z | |
| dc.date.issued | 2018 | |
| dc.identifier.issn | 1439-4227 | |
| dc.identifier.uri | https://dspace.kpfu.ru/xmlui/handle/net/148656 | |
| dc.description.abstract | © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Radiolabeled biomolecules with short half-life times are of increasing importance for positron emission tomography (PET) imaging studies. Herein, we demonstrate an improved and generalized method for synthesizing a [radiometal]-unsaturated aldehyde as a lysine-labeling probe that can be easily conjugated into various biomolecules through the RIKEN click reaction. As a case study, 68Ga-PET imaging of U87MG xenografted mice is demonstrated by using the 68Ga-DOTA-RGDyK peptide, which is selective to αVβ3 integrins. | |
| dc.relation.ispartofseries | ChemBioChem | |
| dc.subject | biomolecules | |
| dc.subject | click chemistry | |
| dc.subject | gallium | |
| dc.subject | positron emission tomography | |
| dc.subject | radiopharmaceuticals | |
| dc.title | Expanding the Applicability of the Metal Labeling of Biomolecules by the RIKEN Click Reaction: A Case Study with Gallium-68 Positron Emission Tomography | |
| dc.type | Article | |
| dc.relation.ispartofseries-issue | 19 | |
| dc.relation.ispartofseries-volume | 19 | |
| dc.collection | Публикации сотрудников КФУ | |
| dc.relation.startpage | 2055 | |
| dc.source.id | SCOPUS14394227-2018-19-19-SID85053628298 |
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Публикации сотрудников КФУ Scopus [24551]
Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.