dc.contributor.author |
Nakamoto Y. |
|
dc.contributor.author |
Pradipta A. |
|
dc.contributor.author |
Mukai H. |
|
dc.contributor.author |
Zouda M. |
|
dc.contributor.author |
Watanabe Y. |
|
dc.contributor.author |
Kurbangalieva A. |
|
dc.contributor.author |
Ahmadi P. |
|
dc.contributor.author |
Manabe Y. |
|
dc.contributor.author |
Fukase K. |
|
dc.contributor.author |
Tanaka K. |
|
dc.date.accessioned |
2019-01-22T20:45:53Z |
|
dc.date.available |
2019-01-22T20:45:53Z |
|
dc.date.issued |
2018 |
|
dc.identifier.issn |
1439-4227 |
|
dc.identifier.uri |
https://dspace.kpfu.ru/xmlui/handle/net/148656 |
|
dc.description.abstract |
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Radiolabeled biomolecules with short half-life times are of increasing importance for positron emission tomography (PET) imaging studies. Herein, we demonstrate an improved and generalized method for synthesizing a [radiometal]-unsaturated aldehyde as a lysine-labeling probe that can be easily conjugated into various biomolecules through the RIKEN click reaction. As a case study, 68Ga-PET imaging of U87MG xenografted mice is demonstrated by using the 68Ga-DOTA-RGDyK peptide, which is selective to αVβ3 integrins. |
|
dc.relation.ispartofseries |
ChemBioChem |
|
dc.subject |
biomolecules |
|
dc.subject |
click chemistry |
|
dc.subject |
gallium |
|
dc.subject |
positron emission tomography |
|
dc.subject |
radiopharmaceuticals |
|
dc.title |
Expanding the Applicability of the Metal Labeling of Biomolecules by the RIKEN Click Reaction: A Case Study with Gallium-68 Positron Emission Tomography |
|
dc.type |
Article |
|
dc.relation.ispartofseries-issue |
19 |
|
dc.relation.ispartofseries-volume |
19 |
|
dc.collection |
Публикации сотрудников КФУ |
|
dc.relation.startpage |
2055 |
|
dc.source.id |
SCOPUS14394227-2018-19-19-SID85053628298 |
|