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dc.contributor.author | Khaziev R. | |
dc.contributor.author | Shtyrlin N. | |
dc.contributor.author | Lodochnikova O. | |
dc.contributor.author | Volobueva N. | |
dc.contributor.author | Chestnova R. | |
dc.contributor.author | Alekseev A. | |
dc.contributor.author | Romanova E. | |
dc.contributor.author | Balakin K. | |
dc.contributor.author | Shtyrlin Y. | |
dc.date.accessioned | 2019-01-22T20:42:25Z | |
dc.date.available | 2019-01-22T20:42:25Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1070-4280 | |
dc.identifier.uri | https://dspace.kpfu.ru/xmlui/handle/net/148376 | |
dc.description.abstract | © 2018, Pleiades Publishing, Ltd. Pyridoxine derivatives, 3-hydroxy-2-methylpyridine-4- and -5-carbohydrazides, were synthesized according to optimized known procedures, and a method for the synthesis of 5-(hydroxymethyl)-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine-6-carbohydrazide was developed. The hydroxymethyl groups in positions 5 and 6 of 2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine showed different reactivities, and only the 6-hydroxymethyl group was selectively oxidized to aldehyde under mild conditions. The lactone ring in 5,6-dihydrofuro[3,4-b]pyridin-7(5H)-one was found to be stable to nucleophiles. The synthesized hydrazides showed no antimycobacterial activity. | |
dc.relation.ispartofseries | Russian Journal of Organic Chemistry | |
dc.title | Synthesis and Antimycobacterial Activity of Hydrazides Based on Pyridoxine Derivatives | |
dc.type | Article | |
dc.relation.ispartofseries-issue | 3 | |
dc.relation.ispartofseries-volume | 54 | |
dc.collection | Публикации сотрудников КФУ | |
dc.relation.startpage | 426 | |
dc.source.id | SCOPUS10704280-2018-54-3-SID85048077606 |