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Silica-coated iron-oxide nanoparticles doped with Gd(III) complexes as potential double contrast agents for magnetic resonance imaging at different field strengths

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dc.date.accessioned 2019-01-22T20:39:19Z
dc.date.available 2019-01-22T20:39:19Z
dc.date.issued 2018
dc.identifier.issn 0974-3626
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/148149
dc.description.abstract © 2018, Indian Academy of Sciences. Abstract: In the present work, we have prepared the ∼ 10 nm superparamagnetic iron-oxide nanoparticles by means of high-temperature decomposition of iron oleate precursor. Then they were coated with silica shell to impart water-solubility and an ability to accommodate paramagnetic Gd(III)-based complexes inside silica coating. All of the prepared nanoparticles form stable in time aqueous dispersions and show good negative or/and positive contrasting effect at different magnetic field strengths (0.47, 1.41, 14.1 T). It has been also exemplified that the incorporation of [Gd(TCAS)] complexes into silica shell triggers a significant increase of the transverse relaxivity of the core–shell nanoparticles. The correlation between relaxometric properties and morphology of the obtained nanoparticles was revealed. The non-toxicity of the obtained nanoparticles along with their ability to shorten both transverse and longitudinal relaxation rates of water protons make them good candidates for their use as dual-mode contrast agents in MRI. Graphical Abstract: [Figure not available: see fulltext.].
dc.relation.ispartofseries Journal of Chemical Sciences
dc.subject Double contrast agents
dc.subject longitudinal relaxivity
dc.subject silica nanoparticles
dc.subject transverse relaxivity
dc.title Silica-coated iron-oxide nanoparticles doped with Gd(III) complexes as potential double contrast agents for magnetic resonance imaging at different field strengths
dc.type Article
dc.relation.ispartofseries-issue 9
dc.relation.ispartofseries-volume 130
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS09743626-2018-130-9-SID85052281028


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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