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Water-soluble polyol-methanofullerenes as mitochondria-targeted antioxidants: Mechanism of action

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dc.date.accessioned 2019-01-22T20:39:02Z
dc.date.available 2019-01-22T20:39:02Z
dc.date.issued 2018
dc.identifier.issn 0960-894X
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/148132
dc.description.abstract © 2018 Elsevier Ltd The mechanism of an antioxidant action of water-soluble polyol – methanofullerenes C60[C9H10O4(OH)4]6 and C60[C13H18O4(OH)4]6 as the mild uncouplers of an oxidative phosphorylation and respiration is postulated. According to this mechanism, hydroxyl group of methanofullerenols can be protonated under excess of protons in the intermembrane space of hyperpolarized mitochondria. Protonation of fullerene derivatives is confirmed by the decrease in their negative Zeta potential in the pH below 5.4. Heavily protonated methanofullerenols become positively charged and move into the mitochondrial matrix. As a consequence, the proton gradient is dissipated, which causes a decrease in mitochondrial transmembrane potential (ΔΨm) and reduction in ROS production.
dc.relation.ispartofseries Bioorganic and Medicinal Chemistry Letters
dc.subject Antioxidant activity
dc.subject Hyperpolarized mitochondria
dc.subject Methanofullerenols
dc.subject Protonation
dc.subject Zeta potential
dc.title Water-soluble polyol-methanofullerenes as mitochondria-targeted antioxidants: Mechanism of action
dc.type Article
dc.relation.ispartofseries-issue 6
dc.relation.ispartofseries-volume 28
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 1097
dc.source.id SCOPUS0960894X-2018-28-6-SID85042113226


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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