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Spontaneous BOLD waves – A novel hemodynamic activity in Sprague-Dawley rat brain detected by functional magnetic resonance imaging

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dc.date.accessioned 2019-01-22T20:36:21Z
dc.date.available 2019-01-22T20:36:21Z
dc.date.issued 2018
dc.identifier.issn 0271-678X
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/147936
dc.description.abstract © 2018, The Author(s) 2018. We report spontaneous hemodynamic activity termed “Spontaneous BOLD Waves” (SBWs) detected by BOLD fMRI in Sprague-Dawley rats under medetomidine anesthesia. These SBWs, which lasted several minutes, were observed in cortex, thalamus and hippocampus. The SBWs’ correlates were undetectable in electrophysiological recordings, suggesting an exclusive gliovascular phenomenon dissociated from neuronal activity. SBWs were insensitive to the NMDA receptors antagonist MK-801 but were inhibited by the α1-adrenoceptor blocker prazosin. Since medetomidine is a potent agonist of α2 adrenoceptors, we suggested that imbalance in α1/α2 receptor-mediated signalling pathways alter the vascular reactivity leading to SBWs. The frequency of SBWs increased with intensity of mechanical lung ventilation despite the stable pH levels. In summary, we present a novel type of propagating vascular brain activity without easily detectable underlying neuronal activity, which can be utilized to study the mechanisms of vascular reactivity in functional and pharmacological MRI and has practical implications for designing fMRI experiments in anesthetized animals.
dc.relation.ispartofseries Journal of Cerebral Blood Flow and Metabolism
dc.subject Blood oxygen level dependent contrast imaging
dc.subject electrophysiology
dc.subject functional magnetic resonance imaging
dc.subject medetomidine
dc.subject neurovascular coupling
dc.title Spontaneous BOLD waves – A novel hemodynamic activity in Sprague-Dawley rat brain detected by functional magnetic resonance imaging
dc.type Article in Press
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS0271678X-2018-SID85047418794


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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