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Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities

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dc.date.accessioned 2019-01-22T20:35:36Z
dc.date.available 2019-01-22T20:35:36Z
dc.date.issued 2018
dc.identifier.issn 0163-7258
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/147867
dc.description.abstract © 2018 The Authors Acute myocardial infarction (AMI) and the heart failure that often follows, are major causes of death and disability worldwide. As such, new therapies are required to limit myocardial infarct (MI) size, prevent adverse left ventricular (LV) remodeling, and reduce the onset of heart failure following AMI. The inflammatory response to AMI, plays a critical role in determining MI size, and a persistent pro-inflammatory reaction can contribute to adverse post-MI LV remodeling, making inflammation an important therapeutic target for improving outcomes following AMI. In this article, we provide an overview of the multiple players (and their dynamic roles) involved in the complex inflammatory response to AMI and subsequent LV remodeling, and highlight future opportunities for targeting inflammation as a therapeutic strategy for limiting MI size, preventing adverse LV remodeling, and reducing heart failure in AMI patients.
dc.relation.ispartofseries Pharmacology and Therapeutics
dc.subject Acute myocardial infarction
dc.subject Acute myocardial ischemia and reperfusion injury
dc.subject Chemokines
dc.subject Cytokines
dc.subject Dendritic cells
dc.subject Inflammation
dc.subject Innate immunity
dc.subject Lymphocytes
dc.subject Macrophages
dc.subject Monocytes
dc.title Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities
dc.type Review
dc.relation.ispartofseries-volume 186
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 73
dc.source.id SCOPUS01637258-2018-186-SID85041589954


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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