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Effect of α<inf>2</inf>-Adrenoceptor Stimulation on Functional Parameters of Langendorff-Isolated Rat Heart
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| dc.contributor.author | Ziyatdinova N. | |
| dc.contributor.author | Kuptsova A. | |
| dc.contributor.author | Faskhutdinov L. | |
| dc.contributor.author | Zefirov A. | |
| dc.contributor.author | Zefirov T. | |
| dc.date.accessioned | 2019-01-22T20:31:52Z | |
| dc.date.available | 2019-01-22T20:31:52Z | |
| dc.date.issued | 2018 | |
| dc.identifier.issn | 0007-4888 | |
| dc.identifier.uri | https://dspace.kpfu.ru/xmlui/handle/net/147583 | |
| dc.description.abstract | © 2018, Springer Science+Business Media, LLC, part of Springer Nature. We studied the effect of α2-adrenoreceptor agonist clonidine hydrochloride in concentrations of 10—9-10—6 M on inotropy, chronotropy, and coronary flow in Langendorff-isolated heart of adult rats. It was found that α2-adrenoreceptor agonist changed all studied parameters. Left ventricular myocardium contraction force decreased after application of all tested concentrations, the maximum effect was observed at a concentration of 10—6 M. Stimulation of α2-adrenergic receptors in concentrations of 10—8, 10—7, and 10—6 M produced a two-phase effect (initial increase and a subsequent decrease) on the coronary flow. Clonidine hydrochloride in the maximum concentration (10—6 M) caused a decrease in HR in one group and an increase in the other. | |
| dc.relation.ispartofseries | Bulletin of Experimental Biology and Medicine | |
| dc.subject | chronotropy | |
| dc.subject | coronary flow | |
| dc.subject | inotropy | |
| dc.subject | isolated heart | |
| dc.subject | α -adrenergic receptors 2 | |
| dc.title | Effect of α<inf>2</inf>-Adrenoceptor Stimulation on Functional Parameters of Langendorff-Isolated Rat Heart | |
| dc.type | Article | |
| dc.relation.ispartofseries-issue | 5 | |
| dc.relation.ispartofseries-volume | 165 | |
| dc.collection | Публикации сотрудников КФУ | |
| dc.relation.startpage | 593 | |
| dc.source.id | SCOPUS00074888-2018-165-5-SID85053708447 |
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Публикации сотрудников КФУ Scopus [24551]
Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.