dc.contributor.author |
Ziyatdinova N. |
|
dc.contributor.author |
Kuptsova A. |
|
dc.contributor.author |
Faskhutdinov L. |
|
dc.contributor.author |
Zefirov A. |
|
dc.contributor.author |
Zefirov T. |
|
dc.date.accessioned |
2019-01-22T20:31:52Z |
|
dc.date.available |
2019-01-22T20:31:52Z |
|
dc.date.issued |
2018 |
|
dc.identifier.issn |
0007-4888 |
|
dc.identifier.uri |
https://dspace.kpfu.ru/xmlui/handle/net/147583 |
|
dc.description.abstract |
© 2018, Springer Science+Business Media, LLC, part of Springer Nature. We studied the effect of α2-adrenoreceptor agonist clonidine hydrochloride in concentrations of 10—9-10—6 M on inotropy, chronotropy, and coronary flow in Langendorff-isolated heart of adult rats. It was found that α2-adrenoreceptor agonist changed all studied parameters. Left ventricular myocardium contraction force decreased after application of all tested concentrations, the maximum effect was observed at a concentration of 10—6 M. Stimulation of α2-adrenergic receptors in concentrations of 10—8, 10—7, and 10—6 M produced a two-phase effect (initial increase and a subsequent decrease) on the coronary flow. Clonidine hydrochloride in the maximum concentration (10—6 M) caused a decrease in HR in one group and an increase in the other. |
|
dc.relation.ispartofseries |
Bulletin of Experimental Biology and Medicine |
|
dc.subject |
chronotropy |
|
dc.subject |
coronary flow |
|
dc.subject |
inotropy |
|
dc.subject |
isolated heart |
|
dc.subject |
α -adrenergic receptors 2 |
|
dc.title |
Effect of α<inf>2</inf>-Adrenoceptor Stimulation on Functional Parameters of Langendorff-Isolated Rat Heart |
|
dc.type |
Article |
|
dc.relation.ispartofseries-issue |
5 |
|
dc.relation.ispartofseries-volume |
165 |
|
dc.collection |
Публикации сотрудников КФУ |
|
dc.relation.startpage |
593 |
|
dc.source.id |
SCOPUS00074888-2018-165-5-SID85053708447 |
|