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Effect of α<inf>2</inf>-Adrenoceptor Stimulation on Functional Parameters of Langendorff-Isolated Rat Heart

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dc.contributor.author Ziyatdinova N.
dc.contributor.author Kuptsova A.
dc.contributor.author Faskhutdinov L.
dc.contributor.author Zefirov A.
dc.contributor.author Zefirov T.
dc.date.accessioned 2019-01-22T20:31:52Z
dc.date.available 2019-01-22T20:31:52Z
dc.date.issued 2018
dc.identifier.issn 0007-4888
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/147583
dc.description.abstract © 2018, Springer Science+Business Media, LLC, part of Springer Nature. We studied the effect of α2-adrenoreceptor agonist clonidine hydrochloride in concentrations of 10—9-10—6 M on inotropy, chronotropy, and coronary flow in Langendorff-isolated heart of adult rats. It was found that α2-adrenoreceptor agonist changed all studied parameters. Left ventricular myocardium contraction force decreased after application of all tested concentrations, the maximum effect was observed at a concentration of 10—6 M. Stimulation of α2-adrenergic receptors in concentrations of 10—8, 10—7, and 10—6 M produced a two-phase effect (initial increase and a subsequent decrease) on the coronary flow. Clonidine hydrochloride in the maximum concentration (10—6 M) caused a decrease in HR in one group and an increase in the other.
dc.relation.ispartofseries Bulletin of Experimental Biology and Medicine
dc.subject chronotropy
dc.subject coronary flow
dc.subject inotropy
dc.subject isolated heart
dc.subject α -adrenergic receptors 2
dc.title Effect of α<inf>2</inf>-Adrenoceptor Stimulation on Functional Parameters of Langendorff-Isolated Rat Heart
dc.type Article
dc.relation.ispartofseries-issue 5
dc.relation.ispartofseries-volume 165
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 593
dc.source.id SCOPUS00074888-2018-165-5-SID85053708447


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  • Публикации сотрудников КФУ Scopus [22633]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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