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Anti-Inflammatory Activity of Novel (S)-Naproxen Derivatives

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dc.contributor.author Cong H.
dc.contributor.author Sibgatullina R.
dc.contributor.author Latypova L.
dc.contributor.author Kurbangalieva A.
dc.contributor.author Ziganshina L.
dc.date.accessioned 2018-09-19T23:13:46Z
dc.date.available 2018-09-19T23:13:46Z
dc.date.issued 2017
dc.identifier.issn 2191-1630
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/146103
dc.description.abstract © 2016, Springer Science+Business Media New York.In order to optimize the study of the anti-inflammatory activity of novel drugs, in the current study, we used simple in vitro test system, which included osmotic and free radical hemolysis of human erythrocytes and human platelets aggregation, to screen for potential anti-inflammatory activity of three newly developed (S)-naproxen derivatives. We selected one of them (L3), which performed in in vitro tests nearly as well as naproxen, and studied their anti-inflammatory effects on in vivo model of inflammation, induced by carragenan. L3 was comparable to naproxen in its anti-inflammatory effects, suggesting that the studied simple inexpensive in vitro tests of erythrocyte osmotic and free radical hemolysis and human platelets aggregation could be used for pre-screening of potential anti-inflammatory agents.
dc.relation.ispartofseries BioNanoScience
dc.subject 2(5H)-furanone
dc.subject Anti-inflammatory drugs
dc.subject Carrageenan
dc.subject Hemolysis
dc.subject Naproxen
dc.subject Platelet aggregation
dc.title Anti-Inflammatory Activity of Novel (S)-Naproxen Derivatives
dc.type Article
dc.relation.ispartofseries-issue 1
dc.relation.ispartofseries-volume 7
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 189
dc.source.id SCOPUS21911630-2017-7-1-SID85017611022

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  • Публикации сотрудников КФУ Scopus [22633]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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