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Inhibitory Effects of Ethanol in the Neonatal Rat Hippocampus In Vivo

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dc.contributor.author Chernova K.
dc.contributor.author Burkhanova G.
dc.contributor.author Zakharov A.
dc.contributor.author Khazipov R.
dc.contributor.author Sitdikova G.
dc.date.accessioned 2018-09-19T23:13:44Z
dc.date.available 2018-09-19T23:13:44Z
dc.date.issued 2017
dc.identifier.issn 2191-1630
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/146102
dc.description.abstract © 2016, Springer Science+Business Media New York.Ethanol-induced neuroapoptosis in the developing brain has been suggested to involve suppression of neuronal activity. However, ethanol acts as a potent stimulant of neuronal activity by increasing the frequency of depolarizing GABA dependent giant depolarizing potentials in the neonatal rat hippocampal slices in vitro. Here, we show that ethanol strongly inhibits, in a dose-dependent manner (1–6 g/kg), sharp waves and multiple unit activity in the hippocampus of neonatal (postnatal days P4–6) rats in vivo. Thus, the effects of ethanol on the developing hippocampal network activity cardinally differ in vitro (stimulation) and in vivo (inhibition).
dc.relation.ispartofseries BioNanoScience
dc.subject Electroencephalography
dc.subject Ethanol
dc.subject Hippocampus
dc.subject Neonate
dc.subject Rat
dc.subject Sharp waves
dc.title Inhibitory Effects of Ethanol in the Neonatal Rat Hippocampus In Vivo
dc.type Article
dc.relation.ispartofseries-issue 1
dc.relation.ispartofseries-volume 7
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 159
dc.source.id SCOPUS21911630-2017-7-1-SID85017608774

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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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