Generation of Plasmid DNA Expressing Species-Specific Horse VEGF164 and FGF2 Factors for Gene Therapy

dc.contributor.author	Litvin Y.
dc.contributor.author	Zakirova E.
dc.contributor.author	Zhuravleva M.
dc.contributor.author	Rizvanov A.
dc.date.accessioned	2018-09-19T23:12:04Z
dc.date.available	2018-09-19T23:12:04Z
dc.date.issued	2016
dc.identifier.issn	2191-1630
dc.identifier.uri	https://dspace.kpfu.ru/xmlui/handle/net/146053
dc.description.abstract	© 2016, Springer Science+Business Media New York.In this study, we have generated a dual expression cassette plasmid DNA (pDNA) construct containing the species-specific horse (Equus caballus) codon optimized sequence encoding potent pro-angiogenic vascular endothelial growth factor (VEGF164) and basic fibroblast growth factor (FGF2) under eukaryotic promoters (EF-1α and CMV promoters, respectively). We have demonstrated effective and simultaneous recombinant proteins expression in vitro. Resulting pDNA is suitable for potential gene therapy applications in horses.
dc.relation.ispartofseries	BioNanoScience
dc.subject	Fibroblast growth factor 2
dc.subject	Gene therapy
dc.subject	Horse
dc.subject	Plasmid DNA
dc.subject	Vascular endothelial growth factor 164
dc.title	Generation of Plasmid DNA Expressing Species-Specific Horse VEGF164 and FGF2 Factors for Gene Therapy
dc.type	Article
dc.relation.ispartofseries-issue	4
dc.relation.ispartofseries-volume	6
dc.collection	Публикации сотрудников КФУ
dc.relation.startpage	550
dc.source.id	SCOPUS21911630-2016-6-4-SID84999836876

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Публикации сотрудников КФУ Scopus [24551]
Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.