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NMR Study of Conformational Structure of Fluvastatin and Its Complex with Dodecylphosphocholine Micelles

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dc.contributor.author Galiullina L.
dc.contributor.author Aganova O.
dc.contributor.author Latfullin I.
dc.contributor.author Musabirova G.
dc.contributor.author Aganov A.
dc.contributor.author Klochkov V.
dc.date.accessioned 2018-09-19T23:11:21Z
dc.date.available 2018-09-19T23:11:21Z
dc.date.issued 2016
dc.identifier.issn 2191-1630
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/146030
dc.description.abstract © 2016, Springer Science+Business Media New York.Fluvastatin is a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. It lowers the overall blood cholesterol level, which is responsible for coronary artery diseases. Conformational features of fluvastatin in water solution were determined. NMR experiments showed that fluvastatin form molecular complex with model cell membrane. It intercalates into membrane surface by its aromatic part. Intermolecular distances between dodecylphosphocholine micelles and fluvastatin nuclei were calculated.
dc.relation.ispartofseries BioNanoScience
dc.subject Fluvastatin
dc.subject Micelles
dc.subject Molecular complex
dc.subject Nuclear magnetic resonance
dc.title NMR Study of Conformational Structure of Fluvastatin and Its Complex with Dodecylphosphocholine Micelles
dc.type Article
dc.relation.ispartofseries-issue 4
dc.relation.ispartofseries-volume 6
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 352
dc.source.id SCOPUS21911630-2016-6-4-SID84999750800


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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