NMR Study of Conformational Structure of Fluvastatin and Its Complex with Dodecylphosphocholine Micelles

dc.contributor.author	Galiullina L.
dc.contributor.author	Aganova O.
dc.contributor.author	Latfullin I.
dc.contributor.author	Musabirova G.
dc.contributor.author	Aganov A.
dc.contributor.author	Klochkov V.
dc.date.accessioned	2018-09-19T23:11:21Z
dc.date.available	2018-09-19T23:11:21Z
dc.date.issued	2016
dc.identifier.issn	2191-1630
dc.identifier.uri	https://dspace.kpfu.ru/xmlui/handle/net/146030
dc.description.abstract	© 2016, Springer Science+Business Media New York.Fluvastatin is a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. It lowers the overall blood cholesterol level, which is responsible for coronary artery diseases. Conformational features of fluvastatin in water solution were determined. NMR experiments showed that fluvastatin form molecular complex with model cell membrane. It intercalates into membrane surface by its aromatic part. Intermolecular distances between dodecylphosphocholine micelles and fluvastatin nuclei were calculated.
dc.relation.ispartofseries	BioNanoScience
dc.subject	Fluvastatin
dc.subject	Micelles
dc.subject	Molecular complex
dc.subject	Nuclear magnetic resonance
dc.title	NMR Study of Conformational Structure of Fluvastatin and Its Complex with Dodecylphosphocholine Micelles
dc.type	Article
dc.relation.ispartofseries-issue	4
dc.relation.ispartofseries-volume	6
dc.collection	Публикации сотрудников КФУ
dc.relation.startpage	352
dc.source.id	SCOPUS21911630-2016-6-4-SID84999750800

Files in this item

Size: 43.90Kb

Format: PDF

Публикации сотрудников КФУ Scopus [24551]
Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.