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Paramagnetic Manganese in the Atherosclerotic Plaque of Carotid Arteries

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dc.contributor.author Chelyshev Y.
dc.contributor.author Gafurov M.
dc.contributor.author Ignatyev I.
dc.contributor.author Zanochkin A.
dc.contributor.author Mamin G.
dc.contributor.author Sorokin B.
dc.contributor.author Sorokina A.
dc.contributor.author Lyapkalo N.
dc.contributor.author Gizatullina N.
dc.contributor.author Mukhamedshina Y.
dc.contributor.author Orlinskii S.
dc.date.accessioned 2018-09-19T23:03:22Z
dc.date.available 2018-09-19T23:03:22Z
dc.date.issued 2016
dc.identifier.issn 2314-6133
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/145945
dc.description.abstract © 2016 Yury Chelyshev et al.The search for adequate markers of atherosclerotic plaque (AP) instability in the context of assessment of the ischemic stroke risk in patients with atherosclerosis of the carotid arteries as well as for solid physical and chemical factors that are connected with the AP stability is extremely important. We investigate the inner lining of the carotid artery specimens from the male patients with atherosclerosis (27 patients, 42-64 years old) obtained during carotid endarterectomy by using different analytical tools including ultrasound angiography, X-ray analysis, immunological, histochemical analyses, and high-field (3.4 T) pulse electron paramagnetic resonance (EPR) at 94 GHz. No correlation between the stable and unstable APs in the sense of the calcification is revealed. In all of the investigated samples, the EPR spectra of manganese, namely, Mn2+ ions, are registered. Spectral and relaxation characteristics of Mn2+ ions are close to those obtained for the synthetic (nano) hydroxyapatite species but differ from each other for stable and unstable APs. This demonstrates that AP stability could be specified by the molecular organization of their hydroxyapatite components. The origin of the obtained differences and the possibility of using EPR of Mn2+ as an AP stability marker are discussed.
dc.relation.ispartofseries BioMed Research International
dc.title Paramagnetic Manganese in the Atherosclerotic Plaque of Carotid Arteries
dc.type Article
dc.relation.ispartofseries-volume 2016
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS23146133-2016-2016-SID85008670884


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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