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The Effects of Haloperidol on Acute Carrageenan-Induced Inflammation

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dc.contributor.author Khaziakhmetova V.
dc.contributor.author Baiysbekov K.
dc.contributor.author Torobekov S.
dc.contributor.author Cong H.
dc.contributor.author Ziganshina L.
dc.date.accessioned 2018-09-19T23:00:03Z
dc.date.available 2018-09-19T23:00:03Z
dc.date.issued 2017
dc.identifier.issn 2191-1630
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/145898
dc.description.abstract © 2017, Springer Science+Business Media New York.The objective of the study was to assess potential anti-inflammatory or pro-inflammatory effects of haloperidol, a classic typical neuroleptic, a butyrophenone derivative. It has been hypothesized that the anti-inflammatory mechanisms of some psychotropic drugs might become a rationale for their use for potential prevention of neurodegenirative diseases, including Alzheimer’s, which are known to include chronic inflammation as disease progression component. We looked at the effects of haloperidol on the acute carrageenan-induced inflammation of rat paws and showed that haloperidol with prolonged use (for 7 days prior to edema modeling) considerably increased the inflammatory response at 48 h. A single dose of haloperidol also stimulated the progression of inflammation but at earlier time points—at 3 and 4 h after carrageenan injection.
dc.relation.ispartofseries BioNanoScience
dc.subject Acute inflammation
dc.subject Carrageenan
dc.subject Haloperidol
dc.subject Rats
dc.title The Effects of Haloperidol on Acute Carrageenan-Induced Inflammation
dc.type Article
dc.relation.ispartofseries-issue 2
dc.relation.ispartofseries-volume 7
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 442
dc.source.id SCOPUS21911630-2017-7-2-SID85019135602


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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